Pharmacophore Guided Docking
This video covers MOE applications for protein-ligand docking, including pharmacophore-guided docking which ensures high-quality docked poses with all key interactions preserved.
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=31&autoplay=1[label]0:31 Loading a PDB Complex[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=51&autoplay=1[label]0:51 Structure preparation with QuickPrep[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=162&autoplay=1[label]2:42 Rendering using the System Manager[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=194&autoplay=1[label]3:14 Protein-Ligand interaction analysis[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=246&autoplay=1[label]4:06 Binding pocket analysis using Surfaces[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=300&autoplay=1[label]5:00 Setting up the unified Dock panel[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=498&autoplay=1[label]8:18 Encoding key interactions using the Pharmacophore Editor[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=801&autoplay=1[label]13:21 Running the docker[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=933&autoplay=1[label]15:33 Quantitative analysis using the Database Viewer[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=1010&autoplay=1[label]16:50 Qualitative analysis using the Database Browser[link end]
[link]video.chemcomp[d]com/watch/AofbRr6kaU44y5HyFTXy9m?second=1078&autoplay=1[label]17:58 Selecting best-docked poses for future reference[link end]
