Homology Modeling
This video shows how to generate a 3D structural model directly from sequence using the MOE Homology Modeler.
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=25&autoplay=1[label]0:25 Loading a sequence[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=47&autoplay=1[label]0:47 Searching for templates[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=154&autoplay=1[label]2:34 Analyzing templates using the Protein Similarity Monitor[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=191&autoplay=1[label]3:11 Analyzing templates using the Sequence Editor Dendrogram[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=232&autoplay=1[label]3:52 Realigning the remaining templates for optimum alignment[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=287&autoplay=1[label]4:47 Running the Homology Modeler[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=483&autoplay=1[label]8:03 Assessing the quality of the structural model using the Protein Geometry application[link end]
[link]video.chemcomp[d]com/watch/DRiop6S1W9B2jFqusPP6tH?second=574&autoplay=1[label]9:34 Assessing different loop conformations of the intermediate models[link end]
