🆕 Pharmacophore-guided Biologics Virtual Screening
This video shows how to screen potential binding partners against a target as an ultra-fast alternative to protein-protein docking. This can be used to screen various modalities including; proteins, antibodies, peptides, and DNA/RNA.
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=48&autoplay=1[label]0:48 Defining the “ligand” for screening [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=59&autoplay=1[label]0:59 Identifying key contacts at the protein-protein Interface using Protein Contacts [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=197&autoplay=1[label]3:07 Encoding key contacts as Pharmacophore features [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=290&autoplay=1[label]4:50 Encoding the target as an excluded volume to prevent clashes [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=312&autoplay=1[label]5:12 Searching a database to identify potential binding partners [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=373&autoplay=1[label]6:13 Inspecting hits from the Database Viewer [link end]
[link]video.chemcomp[d]com/watch/VQcQprj2aGcw1rLoXhp6N2?second=425&autoplay=1[label]7:05 Modifying the pharmacophore to make the query more specific [link end]
