🆕 Sampling and Building Linkers with the Linker Modeler
This video demonstrates how to sample and build linker conformations. The Loop and Linker Modeler can be used to sample loops for homology models, build missing loops for X-ray structures, or generate linkers for fusion proteins. In this example, a linker is constructed between the light and heavy chains of an antibody fragment antigen-binding (Fab) region to generate a single-chain variable fragment (scFv).
[link]video.chemcomp[d]com/watch/9ofxx8WgKD57XUawhdTWyR?second=126&autoplay=1[label]2:06 Running the Linker Modeler [link end]
[link]video.chemcomp[d]com/watch/9ofxx8WgKD57XUawhdTWyR?second=192&autoplay=1[label]3:12 Browsing the backbone conformation of linker candidates [link end]
[link]video.chemcomp[d]com/watch/9ofxx8WgKD57XUawhdTWyR?second=245&autoplay=1[label]4:05 Constructing a G4S linker, building the side chains, and repacking the environment [link end]
