Creating and Analyzing Focused Mutant Libraries for Protein Engineering
Computational techniques for optimizing the affinity of a potential therapeutic protein or antibody are described. Experimental results from phage display may be read into MOE and analyzed to identify promising mutation sites and specific mutations, which can then be explored further individually and in correlation to yield potential new leads with enhanced efficacy. Workflows for these procedures are described and demonstrated.
Airdate: October 28, 2020
