Antibody-Antigen Analysis and Mutations
This video covers MOE applications for analyzing an Ab-Ag complex to identify CDR residue mutations that improve solubility, reduce liabilities whilst maintaining affinity.
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=30&autoplay=1[label]0:30 Loading a PDB complex[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=92&autoplay=1[label]1:32 Structure preparation with QuickPrep[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=226&autoplay=1[label]3:46 Inspecting sequences with the Sequence Editor[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=292&autoplay=1[label]4:52 Annotating the antibody[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=370&autoplay=1[label]6:10 Controlling the Ag with the System Manager[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=465&autoplay=1[label]7:45 Analyzing key interactions using Protein Contacts[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=700&autoplay=1[label]11:40 Analyzing Protein Properties using Surfaces[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=835&autoplay=1[label]13:55 Calculating Protein Patches[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=933&autoplay=1[label]15:33 Analyzing patches using Protein Patch Analyzer[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=1091&autoplay=1[label]18:11 Calculating Protein Properties[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=1442&autoplay=1[label]24:02 Virtual mutagenesis using the Protein Builder[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=1624&autoplay=1[label]27:04 Virtual mutagenesis using Protein Design[link end]
[link]video.chemcomp[d]com/watch/xBfx3DkmLV2HVrC3BB8StX?second=1949&autoplay=1[label]32:29 Analyzing mutants using the Database Browser[link end]
