Fragment Based Drug Design - Scaffold Replacement
This video covers the Fragment-Based Drug Design tools in MOE, specifically using the scaffold replacement operation to replace the central portion of a scaffold.
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=30&autoplay=1[label]0:30 Loading a sequence[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=91&autoplay=1[label]1:31 Structure preparation with QuickPrep[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=205&autoplay=1[label]3:25 Rendering using the System Manager[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=246&autoplay=1[label]4:06 Protein-Ligand interaction analysis[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=285&autoplay=1[label]4:45 Generating a Ligand Interaction diagram[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=351&autoplay=1[label]5:51 Binding pocket analysis using Surfaces[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=448&autoplay=1[label]7:28 Setting up the Scaffold Replacement panel[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=644&autoplay=1[label]10:44 Quantitative analysis using the Database Viewer[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=685&autoplay=1[label]11:25 Qualitative analysis using the Database Browser[link end]
[link]video.chemcomp[d]com/watch/n6WYJLeE6tfXprejbbdMm4?second=785&autoplay=1[label]13:05 Encoding key interactions using the Pharmacophore Editor[link end]
