Antibody and Biologics Design

Antibody-Antigen Analysis and Mutations

This video covers MOE applications for analyzing an Ab-Ag complex to identify CDR residue mutations that improve solubility, re...
Oct-18-2023

Antibody Modeling and Developability Assessment

This video covers the MOE antibody modeler and how to analyze the resulting models for potential liabilities. [link]video.che...
Oct-18-2023

Virtual Mutagenesis: Protein Builder and Protein Design Applications

This video shows how to perform virtual mutations using the Protein Builder and Protein Design applications. [link]video.chem...
Oct-18-2023

How to Build an Fv model from sequence using the Antibody Modeler

This video shows how to generate a 3D structural model directly from sequence using the MOE Antibody Modeler. [link]video.che...
Oct-18-2023

Analyzing protein surfaces for excess charge or hydrophobicity using Protein Patches

This video shows how to analyze protein surfaces for potential developability issues such as aggregation or solubility. [link...
Oct-18-2023

Finding key contacts for a protein-protein interface using Protein Contacts

This video shows how to analyze key contacts between; a protein–protein interface, for a given loop or region, or a specific re...
Oct-18-2023

Building molecules using the Protein Builder

This video shows how to build a peptide from scratch; mutating residues, control backbone geometries, repacking and exploring r...
Feb-01-2024

Preparing a raw PDB file containing a Protein-Protein complex

This video shows how to prepare a raw PDB file containing a Protein-Protein complex (no small molecules present) for use in MOE...
Oct-18-2023

Preparing a raw PDB file containing multiple ligands

This video shows how to prepare a raw PDB file containing more than 1 ligand for use in MOE for tasks such as interactive analy...
Oct-18-2023

Preparing a raw PDB file for use in MOE

This video shows how to prepare a raw PDB file for use in MOE for tasks such as interactive analysis or Docking. [link]video....
Oct-18-2023