Antibody Modeling and Developability Assessment
Antibody candidates often have poor biophysical properties and/or chemical liabilities that cause downstream developability issues. In this demonstration, we model a mouse antibody and identify liability motifs using such as glycosylation PTM sites and we propose statistically appropriate mutations. We then model a panel of 14 IgG4 candidates and select one for improved developability in terms of aggregation and solubility using high-throughput antibody modeling and property calculations.
Airdate: March 24, 2022
