Protein-Protein Docking and Epitope Analysis
The MOE Protein docking application is used to map epitopes and other protein-protein interfaces (PPI). This automatically calculates a PPI fingerprint for each pose. The poses are clustered using the fingerprint, and epitope residues are identified from the top-ranking clusters. The poses can then be annotated in the MOE Window, for browsing through all the top epitopes.
[link]video.chemcomp[d]com/watch/jzKXybdHk37AWJYE8FvtmQ?second=69&autoplay=1[label]1:09 Understanding epitopes and their importance [link end]
[link]video.chemcomp[d]com/watch/jzKXybdHk37AWJYE8FvtmQ?second=349&autoplay=1[label]5:49 Workflow for epitope analysis [link end]
[link]video.chemcomp[d]com/watch/jzKXybdHk37AWJYE8FvtmQ?second=373&autoplay=1[label]6:13 Preparing structures for docking [link end]
[link]video.chemcomp[d]com/watch/jzKXybdHk37AWJYE8FvtmQ?second=760&autoplay=1[label]12:40 Running protein-protein docking [link end]
[link]video.chemcomp[d]com/watch/jzKXybdHk37AWJYE8FvtmQ?second=1141&autoplay=1[label]19:01 Analyzing docking results and epitopes [link end]
Airdate: October 20, 2020
