Analyzing protein surfaces for excess charge or hydrophobicity using Protein Patches
This video shows how to analyze protein surfaces for potential developability issues such as aggregation or solubility.
[link]video.chemcomp[d]com/watch/uwxhfdw8Zx7BAZ7BbmbvG3?second=53&autoplay=1[label]0:53 Visualizing regions of excess charge or hydrophobicity with Protein Patches[link end]
[link]video.chemcomp[d]com/watch/uwxhfdw8Zx7BAZ7BbmbvG3?second=112&autoplay=1[label]1:52 Analyzing protein patches with the Patch Analyzer[link end]
[link]video.chemcomp[d]com/watch/uwxhfdw8Zx7BAZ7BbmbvG3?second=187&autoplay=1[label]3:07 Generating 2D Maps of Protein Patches[link end]
Related Videos
Dec-20-2024
This video shows how to generate a 3D structural model directly from sequence using the MOE Homology Modeler.
[link]video.chem...
Homology Modeling
Nov-12-2024
CCG is pleased to announce the 2024 release of the Molecular Operating Environment, MOE. In this webinar, we will present new f...
New and Enhanced Biologics Features in MOE 2024.06
Oct-24-2024
This video covers how to capture the contents of the MOE window (e.g., viewpoints, rendering, surfaces, ligand properties, and ...
Creating a storyboard and tracking design ideas using Capture
Oct-09-2024
This video shows how to use the Solvent Analysis tool, to predict the location and energetic favorability of water molecules in...
Performing Solvent Analysis on a Protein-Ligand Complex
Oct-03-2024
CCG is pleased to announce the 2024 release of the Molecular Operating Environment, MOE. In this webinar we will present new fe...
New and Enhanced Features in MOE 2024.06
May-03-2024
The webinar covers methods for evaluating, analyzing and refining protein models derived from X -ray crystallographic data. Top...
X-Ray Crystallography - Structure Preparation, Electron Density and Solvent
Feb-09-2024
This video shows how to generate visual representations of molecular surfaces and hotspots with examples applied to a protein-l...
Using Surface and Maps to Understand Properties and HotSpots
Feb-01-2024
This video shows how to build a peptide from scratch; mutating residues, control backbone geometries, repacking and exploring r...
Building molecules using the Protein Builder
Dec-18-2023
Until the advent of GPU-accelerated molecular dynamics, alchemical free energy simulations had not been routinely applied in ea...
Free Energy Calculations with Thermodynamic Integration in MOE using AMBER
Dec-18-2023
Setting up a Molecular Dynamics simulation starting from a protein PDB structure can be challenging. It involves: data preparat...
From Structure to Dynamics Simulation: Running & Visualizing MD Trajectories
Apr-18-2024
The webinar covers methods for analyzing and optimizing peptide-protein interactions in the active site. Using a model system c...
Peptide Binding Analysis and Optimization
Dec-18-2023
In this work, we present a method for modeling antibodies and performing pH-dependent conformational sampling, which can enhanc...
Structure-Based Charge Calculations for Predicting Properties and Profiling Antibody Therapeutics
Nov-21-2023
Protein patch analysis is a computational method for identifying and assessing protein interaction hot spots which may be impli...
Protein Surface Charge and Hydrophobic Patch Analysis
Nov-21-2023
Approaches for analyzing and optimizing antibody models using a knowledge-based approach. The use of a specialized antibody str...
Analyzing and Optimizing Antibody Models using a Knowledge-Based Approach
Nov-21-2023
mAb candidates identified from high-throughput screening or binding affinity optimization often present liabilities for develop...
Developability Assessment & Property Prediction by pH-Dependent Conformational Sampling
Nov-21-2023
mAb candidates identified from high-throughput screening or binding affinity optimization often present liabilities for develop...
Computational Approaches for Optimizing the Developability of Biotherapeutics
Oct-18-2023
This video covers MOE applications for analyzing an Ab-Ag complex to identify CDR residue mutations that improve solubility, re...
Antibody-Antigen Analysis and Mutations
Oct-18-2023
This video covers the MOE antibody modeler and how to analyze the resulting models for potential liabilities.
[link]video.che...