Antibody and Biologics Design

Preparing a raw PDB file containing multiple ligands

This video shows how to prepare a raw PDB file containing more than 1 ligand for use in MOE for tasks such as interactive analy...
Oct-18-2023

Preparing a raw PDB file for use in MOE

This video shows how to prepare a raw PDB file for use in MOE for tasks such as interactive analysis or Docking. [link]video....
Oct-18-2023

Computing molecular properties for a database of small molecules using Calculate Descriptors

This video shows how to compute molecular properties for a database of molecules for tasks such as filtering, building QSAR mod...
Nov-21-2023

Using Surface and Maps to Understand Properties and HotSpots

This video shows how to generate visual representations of molecular surfaces and hotspots with examples applied to a protein-l...
Feb-09-2024

Structure-Based Charge Calculations for Predicting Properties and Profiling Antibody Therapeutics

In this work, we present a method for modeling antibodies and performing pH-dependent conformational sampling, which can enhanc...
Dec-18-2023

New and Enhanced Features in MOE 2024.06

CCG is pleased to announce the 2024 release of the Molecular Operating Environment, MOE. In this webinar we will present new fe...
Oct-03-2024

Antibody Modeling and Developability Assessment

Antibody candidates often have poor biophysical properties and/or chemical liabilities that cause downstream developability iss...
Nov-21-2023

Protein Surface Charge and Hydrophobic Patch Analysis

Protein patch analysis is a computational method for identifying and assessing protein interaction hot spots which may be impli...
Nov-21-2023

Creating and Analyzing Focused Mutant Libraries for Protein Engineering

Computational techniques for optimizing the affinity of a potential therapeutic protein or antibody are described. Experimental...
Nov-21-2023

Developability Assessment & Property Prediction by pH-Dependent Conformational Sampling

mAb candidates identified from high-throughput screening or binding affinity optimization often present liabilities for develop...
Nov-21-2023