Antibody and Biologics Design

Using Surface and Maps to Understand Properties and HotSpots

This video shows how to generate visual representations of molecular surfaces and hotspots with examples applied to a protein-l...
Feb-09-2024

Building molecules using the Protein Builder

This video shows how to build a peptide from scratch; mutating residues, control backbone geometries, repacking and exploring r...
Feb-01-2024

Structure-Based Charge Calculations for Predicting Properties and Profiling Antibody Therapeutics

In this work, we present a method for modeling antibodies and performing pH-dependent conformational sampling, which can enhanc...
Dec-18-2023

Protein Surface Charge and Hydrophobic Patch Analysis

Protein patch analysis is a computational method for identifying and assessing protein interaction hot spots which may be impli...
Nov-21-2023

Creating and Analyzing Focused Mutant Libraries for Protein Engineering

Computational techniques for optimizing the affinity of a potential therapeutic protein or antibody are described. Experimental...
Nov-21-2023

Antibody Modeling and Developability Assessment

Antibody candidates often have poor biophysical properties and/or chemical liabilities that cause downstream developability iss...
Nov-21-2023

Analyzing and Optimizing Antibody Models using a Knowledge-Based Approach

Approaches for analyzing and optimizing antibody models using a knowledge-based approach. The use of a specialized antibody str...
Nov-21-2023

Developability Assessment & Property Prediction by pH-Dependent Conformational Sampling

mAb candidates identified from high-throughput screening or binding affinity optimization often present liabilities for develop...
Nov-21-2023

Computational Approaches for Optimizing the Developability of Biotherapeutics

mAb candidates identified from high-throughput screening or binding affinity optimization often present liabilities for develop...
Nov-21-2023

Protein-Protein Docking and Epitope Analysis

The MOE Protein docking application is used to map epitopes and other protein-protein interfaces (PPI). This automatically calc...
Nov-21-2023