Analyzing and Optimizing Antibody Models using a Knowledge-Based Approach
Approaches for analyzing and optimizing antibody models using a knowledge-based approach. The use of a specialized antibody structural database in conjunction with the MOE Project Search application for generating advanced queries that address N-glycosylation liabilities, hydrophobic patch driven aggregation, structural epitope identification, and CDR H3 modeling will be described. In addition, a method for the high -throughput modeling of antibody models will discussed.
Airdate: November 29, 2018
