Using Structures from Cryo Electron Microscopy for Drug Design
Cryo electron microscopy (Cryo EM) allows structures to be solved rapidly for a new biological target. Many drug discovery projects now use Cryo EM structures as well as X-ray crystal structures in structure-based design exercises. MOE can handle structures produced by both Xray and Cryo EM methods. In this webinar we explain how to load, analyze and prepare Cryo EM structures for structure-based drug design using the Structure Preparation and Protonate3D applications in MOE. The prepared structure is compared with the electron density map to highlight regions of the structure likely to be flexible.
Airdate: February 3, 2022
