Protein, DNA/RNA Modeling

Protein-Protein Docking and Epitope Analysis

The MOE Protein docking application is used to map epitopes and other protein-protein interfaces (PPI). This automatically calc...
Nov-21-2023

Analyzing protein surfaces for excess charge or hydrophobicity using Protein Patches

This video shows how to analyze protein surfaces for potential developability issues such as aggregation or solubility. [link...
Oct-18-2023

Using Surface and Maps to Understand Properties and HotSpots

This video shows how to generate visual representations of molecular surfaces and hotspots with examples applied to a protein-l...
Feb-09-2024

Virtual Mutagenesis: Protein Builder and Protein Design Applications

This video shows how to perform virtual mutations using the Protein Builder and Protein Design applications. [link]video.chem...
Oct-18-2023

Creating and Analyzing Focused Mutant Libraries for Protein Engineering

Computational techniques for optimizing the affinity of a potential therapeutic protein or antibody are described. Experimental...
Nov-21-2023

Preparing a raw PDB file containing multiple ligands

This video shows how to prepare a raw PDB file containing more than 1 ligand for use in MOE for tasks such as interactive analy...
Oct-18-2023

Preparing a raw PDB file containing a Protein-Protein complex

This video shows how to prepare a raw PDB file containing a Protein-Protein complex (no small molecules present) for use in MOE...
Oct-18-2023

Preparing a raw PDB file for use in MOE

This video shows how to prepare a raw PDB file for use in MOE for tasks such as interactive analysis or Docking. [link]video....
Oct-18-2023

Building molecules using the Protein Builder

This video shows how to build a peptide from scratch; mutating residues, control backbone geometries, repacking and exploring r...
Feb-01-2024

Superposing Proteins on Structurally Conserved Regions

This video shows how to align the sequences of two or more proteins and superpose their structures on conserved regions. [lin...
Oct-18-2023