Interactive Structure-Based Peptide Optimization
This video covers MOE applications for interactive structure-based design, including active site visualization, protein-peptide contact analysis and peptide optimization in the receptor pocket.
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=27&autoplay=1[label]0:27 Loading a PDB complex[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=90&autoplay=1[label]1:30 Structure preparation with QuickPrep[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=210&autoplay=1[label]3:30 System setup via the System Manager[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=270&autoplay=1[label]4:30 Protein-Peptide interaction analysis[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=440&autoplay=1[label]7:20 Binding pocket analysis using Surfaces and Maps[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=873&autoplay=1[label]14:33 Displaying Peptide Properties[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=940&autoplay=1[label]15:40 Optimizing peptide design using the Protein Builder[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=1057&autoplay=1[label]17:37 Adjusting placement of sidechains[link end]
[link]video.chemcomp[d]com/watch/LPE4fGMANxfZxerMPcM5Gg?second=1140&autoplay=1[label]19:28 Comparing the optimized peptide to the original co-crystal peptide[link end]
